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Writer's pictureTeresa Mendoza, PharmD

Med of the Week: Naratriptan



Naratriptan feature man with headache

For National Migraine and Headache Awareness Month, we're spotlighting one of the powerful triptans: Naratriptan. Known for its effectiveness in treating acute migraine attacks, this medication is a critical tool in the arsenal against debilitating headaches. Dive in to learn more about Naratriptan, its dental implications, and important considerations for use in your practice:


Generic Name: Naratriptan

Brand Name(s): Amerge

Pronunciation: NAR a TRIP tan


About this drug:

  • Naratriptan is a serotonin 5-HT1 receptor agonist used to treat acute migraine headaches.

  • It will only treat a headache that has already started, and will not prevent headaches or reduce the number of attacks.


Dentistry-related tidbits:

  • Naratriptan may cause xerostomia. Consider prescribing a fluoride supplement if the patient has a high rate of caries and increasing the frequency of dental exams.

  • Always check the patient's blood pressure before starting a procedure. This medication may cause hypertension, including a hypertensive crisis.

  • Narcotics in combination with Naratriptan may increase the risk for serotonin syndrome which can be fatal.

  • Alcohol, narcotics, benzodiazepines, muscle relaxants, and other sedating medications, including over-the-counter, may increase the risk of CNS and/or respiratory depression and diminished psychomotor function when combined with Naratriptan. 

  • Combining Naratriptan with the oxazolidinone antibiotic Linezolid may increase the risk of serotonin syndrome. Hold Naratriptan for 24 hours after the last Linezolid dose.

  • Naratriptan cannot be given if a patient has taken an MAO inhibitor such as Isocarboxazid, Phenelzine, Linezolid, Rasagiline, Tranylcypromine, or Selegiline within the last 2 weeks, as a serious, dangerous medication interaction could occur.

  • Steroids and NSAIDs may increase the risk of hypertension. Before prescribing any medication, use the Rx Check tool to prevent potential drug interactions or adverse effects.


Fun facts:

  • Naratriptan binds to 5-HT1B/1D receptors, leading to cranial vasoconstriction and inhibition of pro-inflammatory neuropeptide (e.g. substance P) release. 

  • Naratriptan should not be combined with another migraine medication used in the last 24 hours.

  • Most triptan doses can be repeated 2 hours after the first dose, except naratriptan has the second to longest half-life so the dose can be repeated 4 hours after the first dose. 


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